Supplementary: Cytokine Therapy

Supplementary Issue

Cytokine-Modulating Strategies and Newer Cytokine Targets for Arthritis Therapy

Cytokines are the key mediators of inflammation in the course of autoimmune arthritis and other immune-mediated diseases. Uncontrolled production of the pro-inflammatory cytokines such as interferon-γ (IFN-γ), tumor necrosis factor α (TNFα), interleukin-6 (IL-6), and IL-17 can promote autoimmune pathology, whereas anti-inflammatory cytokines including IL-4, IL-10, and IL-27 can help control inf...

Perspectives for cytokine antagonist therapy in COPD.

Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease associated with progressive airflow limitation. The main risk factor is tobacco smoking. Anti-inflammatory therapies (e.g. corticosteroids) are based on those developed initially for asthma. In contrast to asthma, they are rather ineffective in improving chronic symptoms and reducing inflammation and lung function decl...

Anti-cytokine therapy in chronic destructive arthritis

Tumor necrosis factor (TNF) and interleukin-1 (IL-1) are considered to be master cytokines in chronic, destructive arthritis. Therapeutic approaches in rheumatoid arthritis (RA) patients have so far focused mainly on TNF, which is a major inflammatory mediator in RA and a potent inducer of IL-1; anti-TNF therapy shows great efficacy in RA patients. However, it is not effective in all patients, ...

Anti-cytokine therapy for prevention of atherosclerosis.

BACKGROUND Currently a chronic inflammation is considered to be the one of the most important reasons of the atherosclerosis progression. A huge amount of researches over the past few decades are devoted to study the various mechanisms of inflammation in the development of atherosclerotic lesions. PURPOSE To review current capabilities of anti-inflammatory therapy for the prevention and treat...